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Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia

Abstract:

Recent advances in single-cell transcriptomics are ideally placed to unravel intratumoral heterogeneity and selective resistance of cancer stem cell (SC) subpopulations to molecularly targeted cancer therapies. However, current single-cell RNA-sequencing approaches lack the sensitivity required to reliably detect somatic mutations. We developed a method that combines high-sensitivity mutation detection with whole-transcriptome analysis of the same single cell. We applied this technique to ana...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nm.4336

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Department:
Oxford, MSD, RDM
Thongjuea, S More by this author
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Department:
Oxford, MSD, RDM
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Department:
Oxford, MSD, RDM
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Department:
Oxford, MSD, RDM
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Funding agency for:
Mustjoki, S
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Funding agency for:
Jacobsen, SEW
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Funding agency for:
Jacobsen, SEW
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Medicine Journal website
Volume:
23
Issue:
6
Pages:
692-702
Publication date:
2017-05-15
Acceptance date:
2017-04-10
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Pubs id:
pubs:695715
URN:
uri:dc9b74c4-49e9-4c2e-ba81-44d7bd08c9c0
UUID:
uuid:dc9b74c4-49e9-4c2e-ba81-44d7bd08c9c0
Local pid:
pubs:695715
Language:
English
Keywords:

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