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Journal article

Role of cytokines in rheumatoid arthritis.

Abstract:

Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that many proinflammatory cytokines such as TNF alpha, IL-1, IL-6, GM-CSF, and chemokines such as IL-8 are abundant in all patients regardless of therapy. This is compensated to some degree by the increased production of anti-inflammatory cytokines such as IL-10 and TGF beta and cytokine inhibitors such as IL-1ra and soluble TNF-R. However, this upregulation in homeostatic regulatory mechanisms is not sufficient as ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Brennan, FM More by this author
Journal:
Annual review of immunology
Volume:
14
Issue:
1
Pages:
397-440
Publication date:
1996-01-05
DOI:
EISSN:
1545-3278
ISSN:
0732-0582
URN:
uuid:dc9adc84-380c-4f77-81b6-14ad9789925a
Source identifiers:
481629
Local pid:
pubs:481629
Language:
English
Keywords:

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