Presence of a multidrug-resistance mutation in an HIV-2 variant infecting a treatment-naive individual in Caio, Guinea Bissau.

Journal article

We report the possible transmission of drug-resistant human immunodeficiency virus type 2. A 66-year-old woman from rural Guinea Bissau who had no obvious antiretroviral exposure was found to harbor a variant with the multidrug-resistance mutation Q151M. Finding this mutation among a drug-naive population presents an important public health issue that needs to be addressed for treatment to be effective.

Authors: Jallow, S; Vincent, T; Leligdowicz, A; De Silva, T; Van Tienen, C

• Publication status: Published
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• Volume: 48
• Issue: 12
• Pages: 1790-1793
• Publication date: 2009-06-01
• DOI: 10.1086/599107
• EISSN: 1537-6591
• ISSN: 1058-4838
• Language: English
• Keywords: Aged; Molecular Sequence Data; Sequence Analysis, DNA; Anti-HIV Agents; Female; Amino Acid Substitution; HIV-2; Humans; HIV Infections; Mutation, Missense; Drug Resistance, Multiple, Viral; Guinea-Bissau