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Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells.

Abstract:

L cells expressing either the A/NT/60/68 nucleoprotein or the A/PR/8/34 (H1) hemagglutinin by DNA mediated gene transfer were used to investigate recognition by influenza A specific cytotoxic T lymphocytes (CTL). A subpopulation of CTL that recognized the H1 hemagglutinin was detected in mice primed with either A/PR/8/34 (H1N1) or A/JAP/305/57 (H2N2) influenza viruses. However, neither CTL from mice primed with A/NT/60/68 (H3N2) nor the recombinant virus X31 (H3N2) showed any activity on L ce...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Carter, NP More by this author
Huddleston, JA More by this author
Brownlee, GG More by this author
Journal:
Cell
Volume:
39
Issue:
1
Pages:
13-25
Publication date:
1984-11-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:dc772cf6-9893-4c30-9d71-9e8395bdb7f6
Source identifiers:
21602
Local pid:
pubs:21602

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