Subcortical volume reduction and cortical thinning 3 months after switching to clozapine in treatment resistant schizophrenia

Journal article

Background: Very preterm birth (VPT; at ≤ 32 weeks’ gestation) occurs during a highly critical stage of brain development, which makes the VPT new-born brain highly vulnerable to insult and long-lasting neurodevelopmental sequelae. Structural and functional brain alterations may be at least partly responsible for the behavioural difficulties described in VPT individuals across the lifespan. However, there is marked heterogeneity in the extent and presence of behavioural difficulties amongst V...

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Authors: Krajner, F; Hadaya, L; McQueen, G; Sendt, K-V; Gillespie, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Schizophrenia
• Volume: 8
• Issue: 1
• Pages: 13-13
• Article number: 13
• Publication date: 2022-03-02
• DOI: 10.1038/s41537-022-00230-2
• EISSN: 2754-6993
• ISSN: 2754-6993
• Language: English
• Keywords: Internal medicine; Glutamate receptor; Thalamus; Ventricle; Cortex (anatomy); Medicine; Schizophrenia (object-oriented programming); Psychology; Anesthesia; Psychiatry; Clozapine; Cerebral cortex; Cardiology; Neuroscience; Putamen