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Tetrahydrobiopterin protects against hypertrophic heart disease independent of myocardial nitric oxide synthase coupling

Abstract:

Nitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide. Nitric oxide synthase uncoupling occurs with chronic pressure overload, and both are ameliorated by exogenous tetrahydrobiopterin (BH4)-a cofactor required for normal nitric oxide synthase function-supporting a pathophysiological link. Genetically augmenting BH4 synthesis in endothelial cells fails to replicate this benefit, indicati...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1161/JAHA.116.003208

Authors


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NHLBI NIH HHS More from this funder
British Heart Foundation More from this funder
Publisher:
Wiley Open Access Publisher's website
Journal:
Journal of the American Heart Association Journal website
Volume:
5
Issue:
3
Pages:
406-410
Publication date:
2016-03-21
Acceptance date:
2016-02-11
DOI:
ISSN:
2047-9980
Pubs id:
pubs:611786
URN:
uri:dc4c96b4-bbac-4d73-88ec-a6f99beda659
UUID:
uuid:dc4c96b4-bbac-4d73-88ec-a6f99beda659
Local pid:
pubs:611786
Paper number:
3

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