Journal article
Tetrahydrobiopterin protects against hypertrophic heart disease independent of myocardial nitric oxide synthase coupling
- Abstract:
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Nitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide. Nitric oxide synthase uncoupling occurs with chronic pressure overload, and both are ameliorated by exogenous tetrahydrobiopterin (BH4)-a cofactor required for normal nitric oxide synthase function-supporting a pathophysiological link. Genetically augmenting BH4 synthesis in endothelial cells fails to replicate this benefit, indicati...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.3MB)
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- Publisher copy:
- 10.1161/JAHA.116.003208
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Authors
Funding
NHLBI NIH HHS
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British Heart Foundation
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Journal of the American Heart Association Journal website
- Volume:
- 5
- Issue:
- 3
- Pages:
- 406-410
- Publication date:
- 2016-03-21
- Acceptance date:
- 2016-02-11
- DOI:
- ISSN:
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2047-9980
- Pmid:
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27001967
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:611786
- UUID:
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uuid:dc4c96b4-bbac-4d73-88ec-a6f99beda659
- Local pid:
- pubs:611786
- Deposit date:
- 2016-08-30
Terms of use
- Copyright holder:
- Toru Hashimoto et al
- Copyright date:
- 2016
- Notes:
-
This is an open access article under the terms of the
Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use,
distribution and reproduction in any medium, provided the original work is
properly cited and is not used for commercial purposes.
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