- Abstract:
-
Nitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide. Nitric oxide synthase uncoupling occurs with chronic pressure overload, and both are ameliorated by exogenous tetrahydrobiopterin (BH4)-a cofactor required for normal nitric oxide synthase function-supporting a pathophysiological link. Genetically augmenting BH4 synthesis in endothelial cells fails to replicate this benefit, indicati...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.3MB)
-
- Publisher copy:
- 10.1161/JAHA.116.003208
-
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- Publisher:
- Wiley Open Access Publisher's website
- Journal:
- Journal of the American Heart Association Journal website
- Volume:
- 5
- Issue:
- 3
- Pages:
- 406-410
- Publication date:
- 2016-03-21
- Acceptance date:
- 2016-02-11
- DOI:
- ISSN:
-
2047-9980
- Pubs id:
-
pubs:611786
- URN:
-
uri:dc4c96b4-bbac-4d73-88ec-a6f99beda659
- UUID:
-
uuid:dc4c96b4-bbac-4d73-88ec-a6f99beda659
- Local pid:
- pubs:611786
- Paper number:
- 3
- Language:
- English
- Keywords:
- Copyright holder:
- Toru Hashimoto et al.
- Copyright date:
- 2016
- Notes:
-
This is an open access article under the terms of the
Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use,
distribution and reproduction in any medium, provided the original work is
properly cited and is not used for commercial purposes.
Journal article
Tetrahydrobiopterin protects against hypertrophic heart disease independent of myocardial nitric oxide synthase coupling
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NHLBI NIH HHS
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British Heart Foundation
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