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The Copper(II)-Catalyzed Oxidation of Glutathione.

Abstract:

The kinetics and mechanisms of the copper(II)-catalyzed GSH (glutathione) oxidation are examined in the light of its biological importance and in the use of blood and/or saliva samples for GSH monitoring. The rates of the free thiol consumption were measured spectrophotometrically by reaction with DTNB (5,5'-dithiobis-(2-nitrobenzoic acid)), showing that GSH is not auto-oxidized by oxygen in the absence of a catalyst. In the presence of Cu(2+) , reactions with two timescales were observed. Th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1002/chem.201603366

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Department:
Oxford, MPLS, Chemistry
Role:
Author
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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
Role:
Author
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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
Role:
Author
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Funding agency for:
Ngamchuea, K
Royal Thai Government More from this funder
Publisher:
Wiley Publisher's website
Journal:
Chemistry - A European Journal Journal website
Volume:
22
Issue:
44
Pages:
15937-15944
Publication date:
2016-09-21
Acceptance date:
2016-08-18
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
Pubs id:
pubs:646030
URN:
uri:dc107579-621d-4dc9-b64f-6878e4d1ec26
UUID:
uuid:dc107579-621d-4dc9-b64f-6878e4d1ec26
Local pid:
pubs:646030

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