Journal article
Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study
- Abstract:
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The Warburg effect is a widely known process in which cancer cells produce energy through anaerobic glycolysis, even in the presence of oxygen which correlates with cancer resistance, aggressiveness, and metastasis. The last reversible reaction of anaerobic glycolysis is the conversion of pyruvate to lactate catalyzed by lactate dehydrogenase A (LDH-A). A high LDH-A expression was shown to be prognostic in various cancers such as thoracic and pancreatic cancers and was associated with shorter...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 3.9MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pcbi.1011944
Authors
+ Wellcome Trust
More from this funder
- Funder identifier:
- 10.13039/100010269
- Grant:
- 215106/Z/18/Z (CEP)
+ H2020 European Research Council
More from this funder
- Funder identifier:
- 10.13039/100010663
- Grant:
- 772970
- Publisher:
- Public Library of Science
- Journal:
- PLoS Computational Biology More from this journal
- Volume:
- 20
- Issue:
- 3
- Pages:
- e1011944-e1011944
- Publication date:
- 2024-03-15
- DOI:
- EISSN:
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1553-7358
- ISSN:
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1553-734X
- Language:
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English
- Keywords:
- Pubs id:
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1836647
- Local pid:
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pubs:1836647
- Source identifiers:
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W4392861898
- Deposit date:
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2026-06-09
- ARK identifier:
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- Copyright date:
- 2024
- Licence:
- CC Attribution (CC BY)
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