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Fibroblast growth factor 2 promotes regeneration of cartilage by attracting mesenchymal stem cells to the site of cartilage injury

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Conference abstract
Abstract:

An important response of cartilage to injury is release of fibroblast growth factor 2 (FGF2) from the pericellular matrix. Deletion of FGF2 in mice, leads to worsening cartilage degradation both spontaneously and after surgical induction of osteoarthritis (OA); thereby indicating a chondroprotective role for FGF2. One mechanism by which FGF2 could protect the joint is by promoting intrinsic repair after injury.


Healing of focal cartilage defects in mice has been shown to be de...

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Publication status:
Published
Peer review status:
Reviewed (other)
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.joca.2018.02.090

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Scammahorn, JJ More by this author
Dell'Accio, F More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Publisher:
Elsevier Publisher's website
Volume:
26
Issue:
S1
Pages:
S37
Publication date:
2018-04-29
Acceptance date:
2018-01-08
DOI:
Pubs id:
pubs:856232
URN:
uri:dbdb76c5-6d92-4038-b35e-ab854b9fe7e7
UUID:
uuid:dbdb76c5-6d92-4038-b35e-ab854b9fe7e7
Local pid:
pubs:856232

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