Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1‐13C]pyruvate and 13C‐urea

Journal article

Purpose To demonstrate the feasibility of imaging a bolus of co‐polarized [1‐13C]pyruvate and 13C‐urea to simultaneously assess both metabolism and perfusion in the rodent heart. Methods Copolarized [1‐13C]pyruvate and 13C‐urea was imaged using a multi‐echo, flow‐sensitized spiral pulse sequence. Healthy rats were scanned in a two‐factor factorial design (n = 12 total; metabolism: overnight fasting versus fed with dichloroacetate injection; perfusion: rest versus adenosine stress‐induced hyperemia). Results Alterations in metabolism were detected by changes in pyruvate metabolism into 13C‐bicarbonate. Statistically independent alterations in perfusion were detected by changes in myocardial pyruvate and urea signals. Conclusion The new pulse sequence was used to obtain maps of metabolism and perfusion in the rodent heart in a single acquisition. This hyperpolarized 13C imaging test is expected to enable new studies in which the cardiac metabolism/perfusion mismatch can be studied in the acute environment.

Authors: Lau, A; Miller, J; Robson, M; Tyler, D

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Wiley Periodical
• Journal: Magnetic Resonance in Medicine
• Volume: 77
• Issue: 1
• Pages: 151-158
• Publication date: 2016-01-07
• Acceptance date: 2015-12-02
• DOI: 10.1002/mrm.26106
• EISSN: 1522-2594
• ISSN: 0740-3194
• Pmid: 26743440
• Language: English
• Keywords: SBTMR; hyperpolarization; cardiac; 13C; first-pass perfusion; metabolism