Bone marrow-derived myofibroblasts contribute functionally to scar formation after myocardial infarction.

Journal article

Myofibroblasts play a major role in scar formation during wound healing after myocardial infarction (MI). Their origin has been thought to be interstitial cardiac fibroblasts. However, the bone marrow (BM) can be a source of myofibroblasts in a number of organs after injury. We have studied the temporal, quantitative and functional role of BM-derived (BMD) myofibroblasts in myocardial scar formation. MI was induced by permanent coronary artery ligation in mice reconstituted with EGFP or pro-C...

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Authors: van Amerongen, M; Bou-Gharios, G; Popa, E; van Ark, J; Petersen, A

• Publication status: Published
• Journal: Journal of pathology
• Volume: 214
• Issue: 3
• Pages: 377-386
• Publication date: 2008-02-01
• DOI: 10.1002/path.2281
• EISSN: 1096-9896
• ISSN: 0022-3417
• Language: English
• Keywords: Gene Expression; Bone Marrow Cells; Collagen; Fibroblasts; Immunohistochemistry; Cicatrix; Green Fluorescent Proteins; Mice, Transgenic; Myocardial Infarction; Luciferases; Collagen Type I; Myocardium; Animals; beta-Galactosidase; Actins; Mice, Inbred C57BL; Models, Animal; Wound Healing; Male; Ligation; Mice