Journal article
Convergent pathways in Parkinson’s disease
- Abstract:
- Preferential degeneration of dopamine neurons (DAn) in the midbrain represents the principal hallmark of Parkinson's disease (PD). It has been hypothesized that major contributors to DAn vulnerability lie in their unique cellular physiology and architecture, which make them particularly susceptible to stress factors. Here, we report a concise overview of some of the cell mechanisms that may exacerbate DAn sensitivity and loss in PD. In particular, we highlight how defective protein sorting and clearance, endoplasmic reticulum stress, calcium dyshomeostasis and intracellular trafficking converge to contribute synergistically to neuronal dysfunction in PD pathogenesis.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, pdf, 904.0KB, Terms of use)
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- Publisher copy:
- 10.1007/s00441-017-2700-2
Authors
- Publisher:
- Springer Berlin Heidelberg
- Journal:
- Cell and Tissue Research More from this journal
- Volume:
- 373
- Issue:
- 1
- Pages:
- 79–90
- Publication date:
- 2017-10-23
- Acceptance date:
- 2017-09-11
- DOI:
- EISSN:
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1432-0878
- ISSN:
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0302-766X
- Pmid:
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29063175
- Language:
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English
- Keywords:
- Pubs id:
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pubs:742128
- UUID:
-
uuid:db6025ad-7d2d-4ae5-bd80-6562441e2cb1
- Local pid:
-
pubs:742128
- Deposit date:
-
2017-11-09
Terms of use
- Copyright holder:
- Cherubini and Wade-Martins
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 The Authors.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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