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Phenotypic analysis of perennial airborne allergen-specific CD4 + T cells in atopic and non-atopic individuals

Abstract:

Background Accumulating evidence suggests that T cells play an important role in the pathogenesis of atopic dermatitis (AD); yet, little is known of the differentiation status of CD4 + T cells specific for common environmental allergens, such as the major cat allergen, Fel d 1. Objective To determine the frequency, differentiation phenotype and function of circulating Fel d 1-specific CD4 + T cells in adult individuals with severe persistent AD in comparison with healthy controls. Methods Usi...

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Journal:
Clinical and Experimental Allergy
Volume:
41
Issue:
11
Pages:
1555-1567
Publication date:
2011-11-05
DOI:
EISSN:
1365-2222
ISSN:
0954-7894
URN:
uuid:db443984-4b64-4c2a-8eba-53a0885c0f96
Source identifiers:
192985
Local pid:
pubs:192985

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