Birthweight, vitamin D receptor genotype and the programming of osteoporosis.

Journal article

Studies of the association between polymorphisms of the gene for the vitamin D receptor (VDR) and adult bone mass have been inconsistent, pointing to the possibility that gene--environment interactions may vary in different populations. We have demonstrated previously an association between weight in infancy (a marker of the intrauterine and early post-natal environment) and each of adult bone mass and VDR genotype. We therefore sought to extend these observations in an elderly UK cohort and ...

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Authors: Dennison, E; Arden, N; Keen, R; Syddall, H; Day, I

• Publication status: Published
• Journal: Paediatric and perinatal epidemiology
• Volume: 15
• Issue: 3
• Pages: 211-219
• Publication date: 2001-07-01
• DOI: 10.1046/j.1365-3016.2001.00350.x
• EISSN: 1365-3016
• ISSN: 0269-5022
• Language: English
• Keywords: Female; Humans; Bone Density; Prenatal Exposure Delayed Effects; Pregnancy; Genotype; Receptors, Calcitriol; Birth Weight; Cohort Studies; Nutrition Disorders; Middle Aged; Osteoporosis; Fetal Diseases; Lumbar Vertebrae; Aged; Environment; Algorithms; Male