Mathematical models in physiology.

Journal article

Computational modelling of biological processes and systems has witnessed a remarkable development in recent years. The search-term (modelling OR modeling) yields over 58000 entries in PubMed, with more than 34000 since the year 2000: thus, almost two-thirds of papers appeared in the last 5-6 years, compared to only about one-third in the preceding 5-6 decades. The development is fuelled both by the continuously improving tools and techniques available for bio-mathematical modelling and by the increasing demand in quantitative assessment of element inter-relations in complex biological systems. This has given rise to a worldwide public domain effort to build a computational framework that provides a comprehensive theoretical representation of integrated biological function-the Physiome. The current and next issues of this journal are devoted to a small sub-set of this initiative and address biocomputation and modelling in physiology, illustrating the breadth and depth of experimental data-based model development in biological research from sub-cellular events to whole organ simulations.

Authors: Gavaghan, D; Garny, A; Maini, P; Kohl, P

• Publication status: Published
• Journal: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
• Volume: 364
• Issue: 1842
• Pages: 1099-1106
• Publication date: 2006-05-01
• DOI: 10.1098/rsta.2006.1757
• EISSN: 1471-2962
• ISSN: 1364-503X
• Language: English
• Keywords: Physiology; Mathematics; Models, Biological; Computer Simulation; Systems Biology