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Journal article

Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria.

Abstract:

Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria vaccines. Unfortunately, repeated success of such vaccines in mice has not translated readily to effective malaria vaccines in humans. Thus, mice may be used better as models to dissect basic parameters required for immunity to Plasmodium-infection than as preclinical vaccine models. In turn, this basic information may ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0805452105

Authors


Schmidt, NW More by this author
Podyminogin, RL More by this author
Butler, NS More by this author
Badovinac, VP More by this author
Tucker, BJ More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
105
Issue:
37
Pages:
14017-14022
Publication date:
2008-09-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:daf0e8e1-aea1-44e7-b67a-a760a26c1b1a
Source identifiers:
40932
Local pid:
pubs:40932

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