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Characterization of genetically modified human retinal pigment epithelial cells developed for in vitro and transplantation studies.

Abstract:

PURPOSE: To develop, by specific genetic modification, a differentiated human retinal pigment epithelial (RPE) cell line with an extended life span that can be used for investigating their function in vitro and for in vivo transplantation studies. METHODS: Primary human RPE cells were genetically modified by transfecting with a plasmid encoding the simian virus (SV)40 large T antigen. After characterization, two cell lines, designated h1RPE-7 and h1RPE-116, were chosen for further investigat...

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Publication status:
Published

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Authors


Winton, HL More by this author
Beauchéne, L More by this author
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Journal:
Investigative ophthalmology and visual science
Volume:
43
Issue:
2
Pages:
546-555
Publication date:
2002-02-05
EISSN:
1552-5783
ISSN:
0146-0404
URN:
uuid:daa93f91-6a2c-41b0-91dd-fc9533127ce8
Source identifiers:
251606
Local pid:
pubs:251606

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