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Journal article

Resistance to herpes stromal keratitis conferred by an IgG2a-derived peptide.

Abstract:

Not all peripheral tissue antigens enter the thymus and it is unclear how the immune system remains tolerant to this class of self antigen. As tolerance to self peptides can generate gaps in the T-cell repertoire for cross-reactive foreign antigens, we investigated whether this mechanism might also diminish autoimmune reactions to similar peptides expressed by peripheral tissues. Herpes stromal keratitis (HSK) is a virally induced autoimmune reaction against corneal tissues mediated by T cell...

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Publication status:
Published

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Publisher copy:
10.1038/376431a0

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Nature
Volume:
376
Issue:
6539
Pages:
431-434
Publication date:
1995-08-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:daa90091-de0a-4036-b1c2-7b36d6b6a60b
Source identifiers:
26312
Local pid:
pubs:26312

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