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The effects of Xenon gas inhalation on neuropathology in a placental‐induced brain injury model in neonates: A pilot study

Abstract:
Improved obstetric and neonatal care have reduced the prevalence of severe hypoxic-ischemic-encephalopathy (HIE), however 1-3/1000 newborns in the developed world(1) suffer death or neurodevelopmental disability from HIE. The normal development of the brain during gestation can also be altered by placental reprogramming under oxidative stress. Under these conditions, the placenta releases DNA damaging molecules, bone morphogenic proteins, microRNAs, and glutamate(2). At present, one is unable to diagnose or treat these factors.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/apa.15486

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Role:
Author
ORCID:
0000-0002-9615-9109


Publisher:
Wiley
Journal:
Acta Paediatrica More from this journal
Volume:
110
Issue:
1
Pages:
119-122
Publication date:
2020-07-18
Acceptance date:
2020-07-14
DOI:
EISSN:
1651-2227
ISSN:
0803-5253
Pmid:
32681542


Language:
English
Keywords:
Pubs id:
1120913
Local pid:
pubs:1120913
Deposit date:
2020-07-24

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