Journal article
Ultrasonic enhancement of photoacoustic emissions by nanoparticle-targeted cavitation
- Abstract:
- A technique to enhance the photoacoustic emissions from laser-heated nanoparticles is presented. Gold nano particle-doped phantoms are subjected to pulsed optical and ultrasound fields, resulting in bubble formation and collapse and producing strong acoustic emissions. The applied ultrasound field allows for cavitation at lower laser fluences than using light alone. The acoustic emission associated with bubble collapse well exceeds the direct photoacoustic response and is used to image a nanoparticle-doped region in a tissue phantom. The strong acoustic emission and low-threshold fluence associated with ultrasound-assisted cavitation make the technique well suited for nanoparticle-targeted biological imaging and tissue therapy.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 586.6KB, Terms of use)
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- Publisher copy:
- 10.1364/ol.35.002127
Authors
- Publisher:
- Optical Society of America
- Journal:
- Optics Letters More from this journal
- Volume:
- 35
- Issue:
- 13
- Pages:
- 2127-2129
- Publication date:
- 2010-06-16
- Acceptance date:
- 2010-05-25
- DOI:
- EISSN:
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1539-4794
- ISSN:
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0146-9592
- Pmid:
-
20596168
- Language:
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English
- Keywords:
- Pubs id:
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pubs:430548
- UUID:
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uuid:da99dd84-6907-4f03-be48-8ab54cf74531
- Local pid:
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pubs:430548
- Source identifiers:
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430548
- Deposit date:
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2018-11-12
Terms of use
- Copyright holder:
- Optical Society of America
- Copyright date:
- 2010
- Notes:
- Copyright © 2010 Optical Society of America. This is the accepted manuscript version of the article. The final version is available online from Optical Society of America at: https://doi.org/10.1364/ol.35.002127
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