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Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase.

Abstract:

Acyl-enzyme complexes are intermediates in reactions catalyzed by many hydrolases and related enzymes which employ nucleophilic catalysis. However, most of the reported structural data on acyl-enzyme complexes has been acquired under noncatalytic conditions. Recent IR analyses have indicated that some acyl-enzyme complexes may be more flexible than most crystallographic analyses have implied. OAT2 is a member of the N-terminal nucleophile (Ntn) hydrolase enzyme superfamily and catalyzes the r...

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Publication status:
Published

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Publisher copy:
10.1021/ja807215u

Authors


Clifton, IJ More by this author
Bagonis, M More by this author
Kershaw, NJ More by this author
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Journal:
Journal of the American Chemical Society
Volume:
131
Issue:
2
Pages:
749-757
Publication date:
2009-01-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:da7c7288-b39e-40b8-b7bc-f6ff73cf06fb
Source identifiers:
34535
Local pid:
pubs:34535

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