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Free energy landscape of lipid interactions with regulatory binding sites on the transmembrane domain of the EGF receptor

Abstract:

Lipid molecules can bind to specific sites on integral membrane proteins, modulating their structure and function. We have undertaken coarse-grained simulations to calculate free energy profiles for glycolipids and phospholipids interacting with modulatory sites on the transmembrane helix dimer of the EGF receptor within a lipid bilayer environment. We identify lipid interaction sites at each end of the transmembrane domain, and compute interaction free energy profiles for lipids with these...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1021/acs.jpcb.6b01387

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Biotechnology and Biological Sciences Research Council More from this funder
Engineering and Physical Sciences Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Physical Chemistry B Journal website
Publication date:
2016-01-01
DOI:
EISSN:
1520-5207
ISSN:
1520-6106
URN:
uuid:da077b2d-4db0-4d05-b493-89442bbd2518
Source identifiers:
617710
Local pid:
pubs:617710

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