Journal article
Safety and efficacy of single-dose primaquine to interrupt Plasmodium falciparum malaria transmission in children compared with adults: a systematic review and individual patient data meta-analysis
- Abstract:
-
Background
Adding a single dose of primaquine to artemisinin-based combination therapy (ACT) for the treatment of falciparum malaria can reduce the transmission of Plasmodium falciparum and could limit the spread of artemisinin partial resistance, including in Africa, where the disease burden is greatest. We aimed to compare the safety and efficacy of single-dose primaquine plus ACT between young children (aged <5 years) and older children (aged 5 years to <... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 236.1KB, Terms of use)
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(Preview, Supplementary materials, pdf, 1.4MB, Terms of use)
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- Publisher copy:
- 10.1016/s1473-3099(25)00078-7
Authors
Contributors
+ Price, RN
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Sub department:
- Tropical Medicine
- Role:
- Contributor
+ European Union
More from this funder
- Funder identifier:
- https://ror.org/019w4f821
- Grant:
- 101103076
- Programme:
- Global Health EDCTP3 Joint Undertaking
+ Gates Foundation
More from this funder
- Funder identifier:
- https://ror.org/0456r8d26
- Grant:
- OPP1181807
- Publisher:
- Elsevier
- Journal:
- Lancet Infectious Diseases More from this journal
- Volume:
- 25
- Issue:
- 9
- Pages:
- 965-976
- Place of publication:
- United States
- Publication date:
- 2025-04-23
- Acceptance date:
- 2025-01-30
- DOI:
- EISSN:
-
1474-4457
- ISSN:
-
1473-3099
- Pmid:
-
40286803
- Language:
-
English
- Pubs id:
-
2120005
- Local pid:
-
pubs:2120005
- Deposit date:
-
2025-05-13
- ARK identifier:
Terms of use
- Copyright holder:
- Yilma et al.
- Copyright date:
- 2025
- Rights statement:
- © 2025 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
- Licence:
- CC Attribution (CC BY)
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