Journal article
Xpert MTB/RIF ultra for the diagnosis of tuberculous meningitis: a small step forward
- Abstract:
- The delayed diagnosis of tuberculous meningitis (TBM) leads to poor outcomes, yet the current diagnostic methods for identifying Mycobacterium tuberculosis in cerebrospinal fluid (CSF) are inadequate. The first comparative study of the new GeneXpert MTB/RIF Ultra (Xpert Ultra) for TBM diagnosis suggested increased sensitivity of Xpert Ultra. Two subsequent studies have shown Xpert Ultra has improved sensitivity, but has insufficient negative predictive value to exclude TBM. Collecting and processing large volumes of CSF for mycobacterial testing are important for optimal diagnostic test performance. But clinical, radiological, and laboratory parameters remain essential for TBM diagnosis and empiric therapy is often needed. We therefore caution against the use of Xpert Ultra as a single diagnostic test for TBM; it cannot be used to “rule out” TBM.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 140.6KB, Terms of use)
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- Publisher copy:
- 10.1093/cid/ciaa473
Authors
- Publisher:
- Oxford University Press
- Journal:
- Clinical Infectious Diseases More from this journal
- Volume:
- 71
- Issue:
- 8
- Pages:
- 2002-2005
- Publication date:
- 2020-06-16
- Acceptance date:
- 2020-04-22
- DOI:
- EISSN:
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1537-6591
- ISSN:
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1537-6591
- Pmid:
-
32543658
- Language:
-
English
- Keywords:
- Pubs id:
-
1113869
- Local pid:
-
pubs:1113869
- Deposit date:
-
2020-07-06
Terms of use
- Copyright holder:
- Donovan et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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