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Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly.

Abstract:

Synapse formation and maturation requires bidirectional communication across the synaptic cleft. The trans-synaptic Neurexin-Neuroligin complex can bridge this cleft, and severe synapse assembly deficits are found in Drosophila melanogaster neuroligin (Nlg1, dnlg1) and neurexin (Nrx-1, dnrx) mutants. We show that the presynaptic active zone protein Syd-1 interacts with Nrx-1 to control synapse formation at the Drosophila neuromuscular junction. Mutants in Syd-1 (RhoGAP100F, dsyd-1), Nrx-1 and...

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Publisher copy:
10.1038/nn.3183

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Khorramshahi, O More by this author
Banovic, D More by this author
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Journal:
Nature neuroscience
Volume:
15
Issue:
9
Pages:
1219-1226
Publication date:
2012-09-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:d9d24f00-fdaf-44f2-95e7-4243e1b6f50a
Source identifiers:
345843
Local pid:
pubs:345843

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