Neuroscience & Neuroimaging Research Collection

Journal article : Editorial

What can UK Biobank’s 500 000 participants teach us about chronic pain?

Abstract:: The UK Biobank is increasingly used for the study of chronic pain, yet many clinicians and researchers are unfamiliar with the strengths and limitations of this cohort. Here, we provide practical guidance for interpreting UK Biobank pain research, highlighting key examples of how the UK Biobank has advanced our understanding of pain. We describe the available pain assessments, compare the UK Biobank with other population cohorts, and discuss key methodological considerations, including selection bias, collider effects, and temporal misalignment between data modalities. When interpreted appropriately and triangulated with complementary study designs, the UK Biobank represents a valuable resource for advancing our understanding of the epidemiology, outcomes, and treatment of chronic pain.

Publication status:: Published

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APA Style

Kelleher, E. M., & Irani, A. (2026). What can UK Biobank’s 500 000 participants teach us about chronic pain? British Journal of Anaesthesia, 136(6), 1744–1752.

MLA Style

Kelleher, EM, and A Irani. “What Can UK Biobank’s 500 000 Participants Teach Us about Chronic Pain?” British Journal of Anaesthesia, vol. 136, no. 6, 2026, pp. 1744–52.

Chicago Style

Kelleher, EM, and A Irani. 2026. “What Can UK Biobank’s 500 000 Participants Teach Us about Chronic Pain?” British Journal of Anaesthesia 136 (6): 1744–52.
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Files:: Kelleher_and_Irani_2026_What_can_UK.pdf

(Preview, Accepted manuscript, pdf, 364.7KB, Terms of use)

Publisher copy:: 10.1016/j.bja.2026.02.027

Authors

+ Kelleher, EM More by this author

Role:: Author

+ Irani, A More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDORMS
Sub department:: Botnar Institute for Musculoskeletal Sciences
Oxford college:: Green Templeton College
Role:: Author
ORCID:: 0000-0002-7831-4208

+ British Journal of Anaesthesia More from this funder

Publisher:: Elsevier
Journal:: British Journal of Anaesthesia More from this journal
Volume:: 136
Issue:: 6
Pages:: 1744-1752
Publication date:: 2026-04-13
Acceptance date:: 2026-02-16
DOI:: 10.1016/j.bja.2026.02.027
EISSN:: 1471-6771
ISSN:: 0007-0912

Language:: English
Keywords:: chronic

pain

cohort study

epidemiology

neuroimaging

UK Biobank
Subtype:: Editorial
Pubs id:: 2406271
Local pid:: pubs:2406271
Deposit date:: 2026-06-29
ARK identifier:: ark:/29072/ora_d9c4f3fdb8be4d8dae802f2b072f4446

Terms of use

Copyright holder:: British Journal of Anaesthesia
Copyright date:: 2026
Rights statement:: © 2026 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Notes:: The author accepted manuscript (AAM) of this paper has been made available under the University of Oxford's Open Access Publications Policy, and a CC BY public copyright licence has been applied.

Licence:: CC Attribution (CC BY)

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