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Selective enhancement of the activity of C-terminally truncated, but not intact, acetylcholinesterase.

Abstract:

Acetylcholinesterase (AChE) is one of the fastest enzymes approaching the catalytic limit of enzyme activity. The enzyme is involved in the terminal breakdown of the neurotransmitter acetylcholine, but non-enzymatic roles have also been described for the entire AChE molecule and its isolated C-terminal sequences. These non-cholinergic functions have been attributed to both the developmental and degenerative situation: the major form of AChE present in these conditions is monomeric. Moreover, ...

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Publication status:
Published

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Authors


Zimmermann, M More by this author
Grösgen, S More by this author
Westwell, MS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Journal of neurochemistry
Volume:
104
Issue:
1
Pages:
221-232
Publication date:
2008-01-05
DOI:
EISSN:
1471-4159
ISSN:
0022-3042
URN:
uuid:d9c3ae05-5fb3-46d3-b19a-f93d4118f464
Source identifiers:
185212
Local pid:
pubs:185212

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