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Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors.

Abstract:

BACKGROUND: Traditionally, vaccine development against the blood-stage of Plasmodium falciparum infection has focused on recombinant protein-adjuvant formulations in order to induce high-titer growth-inhibitory antibody responses. However, to date no such vaccine encoding a blood-stage antigen(s) alone has induced significant protective efficacy against erythrocytic-stage infection in a pre-specified primary endpoint of a Phase IIa/b clinical trial designed to assess vaccine efficacy. Cell-me...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0031208

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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
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Institution:
University of Oxford
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Funding agency for:
Duncan, CJ
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Funding agency for:
Hill, AV
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS One Journal website
Volume:
7
Issue:
2
Pages:
Article: e31208
Publication date:
2012
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:d9c03039-aa17-4fab-95d8-ddc5c792d23d
Source identifiers:
312882
Local pid:
pubs:312882

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