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Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.

Abstract:

BACKGROUND: Interleukin-32 (IL-32) is a newly described cytokine produced after stimulation by IL-2 or IL-18 and IFN-gamma. IL-32 has the typical properties of a pro-inflammatory mediator and although its role in rheumatoid arthritis has been recently reported its effect on the osteoclastogenesis process remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we have shown that IL-32 was a potent modulator of osteoclastogenesis in vitro, whereby it promoted the differentiation...

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Publication status:
Published

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Authors


Mabilleau, G More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
PloS one
Volume:
4
Issue:
1
Pages:
e4173
Publication date:
2009
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:d9bd71aa-a407-4057-830a-d7cb90a848b2
Source identifiers:
103892
Local pid:
pubs:103892

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