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Isolation and characterization of the positive-sense replicative intermediate of a negative-strand RNA virus.

Abstract:

Negative-strand RNA viruses represent a significant class of important pathogens that cause substantial morbidity and mortality in human and animal hosts worldwide. A defining feature of these viruses is that their single-stranded RNA genomes are of opposite polarity to messenger RNA and are replicated through a positive-sense intermediate. The replicative intermediate is thought to exist as a complementary ribonucleoprotein (cRNP) complex. However, isolation of such complexes from infected c...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1315068110

Authors


Hengrung, N More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Huiskonen, JT More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
110
Issue:
45
Pages:
E4238-E4245
Publication date:
2013-11-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:d99cee12-e3c8-4c62-9852-2c2dd5f736db
Source identifiers:
435150
Local pid:
pubs:435150

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