Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice

Journal article

Abstract Aims/hypothesis Diabetic cardiomyopathy (DCM) is a serious and under-recognised complication of diabetes. The first sign is diastolic dysfunction, which progresses to heart failure. The pathophysiology of DCM is incompletely understood but microcirculatory changes are important. Endothelial glycocalyx (eGlx) plays multiple vital roles in the microcirculation, including in the regulation of vascular permeability, and is compromised in diabetes but has n...

Expand abstract

Authors: Qiu, Y; Buffonge, S; Ramnath, R; Jenner, S; Fawaz, S

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer
• Journal: Diabetologia
• Volume: 65
• Issue: 5
• Pages: 879-894
• Publication date: 2022-02-25
• DOI: 10.1007/s00125-022-05650-4
• EISSN: 1432-0428
• ISSN: 0012-186X
• Language: English
• Keywords: Streptozotocin; Endocrinology; Cardiac function curve; Perfusion; Pathology; Medicine; Internal medicine; Glycocalyx; Cardiology; Cardiomyopathy; Microcirculation; Immunology; Diabetes mellitus; Endothelial dysfunction; Vascular permeability; Diabetic cardiomyopathy; Heart failure