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Targeting gene expression to hypoxic tumor cells.

Abstract:

Solid tumors with areas of low oxygen tension (hypoxia) have a poor prognosis, as cells in this environment often survive radiation and chemotherapy. In this report we describe how this hypoxic environment can be used to activate heterologous gene expression driven by a hypoxia-responsive element (HRE), which interacts with the transcriptional complex hypoxia-inducible factor-1 (HIF-1). Our results demonstrate that the HIF-1/HRE system of gene regulation is active in hypoxic tumor cells and s...

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Publication status:
Published

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Publisher copy:
10.1038/nm0597-515

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
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Journal:
Nature medicine
Volume:
3
Issue:
5
Pages:
515-520
Publication date:
1997-05-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:d9963137-8ea4-4013-93ad-37c7acfadc65
Source identifiers:
29406
Local pid:
pubs:29406

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