Journal article
Clinically relevant patient clusters identified by machine learning from the clinical development programme of secukinumab in psoriatic arthritis
- Abstract:
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Objectives Identify distinct clusters of psoriatic arthritis (PsA) patients based on their baseline articular, entheseal and cutaneous disease manifestations and explore their clinical and therapeutic value. Methods Pooled baseline data in PsA patients (n=1894) treated with secukinumab across four phase 3 studies (FUTURE 2–5) were analysed to determine phenotypes based on clusters of clinical indicators. Finite mixture models methodology was applied to generate clinical clusters and mean lon...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Supplementary materials, 574.3KB, Terms of use)
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(Preview, Version of record, 2.1MB, Terms of use)
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- Publisher copy:
- 10.1136/rmdopen-2021-001845
Authors
Bibliographic Details
- Publisher:
- BMJ Publishing Group
- Journal:
- RMD Open More from this journal
- Volume:
- 7
- Issue:
- 3
- Article number:
- e001845
- Publication date:
- 2021-11-18
- Acceptance date:
- 2021-10-29
- DOI:
- EISSN:
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2056-5933
- Pmid:
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34795065
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1210787
- Local pid:
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pubs:1210787
- Deposit date:
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2021-12-02
Terms of use
- Copyright holder:
- Pournara et al.
- Copyright date:
- 2021
- Rights statement:
- © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
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