- Abstract:
-
To discover leads for next-generation chemoprotective antimalarial drugs, we tested more than 500,000 compounds for their ability to inhibit liver-stage development of luciferase-expressing Plasmodium spp. parasites (681 compounds showed a half-maximal inhibitory concentration of less than 1 micromolar). Cluster analysis identified potent and previously unreported scaffold families as well as other series previously associated with chemoprophylaxis. Further testing through multiple phenotypic...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.2MB)
-
- Publisher copy:
- 10.1126/science.aat9446
-
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- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Journal website
- Volume:
- 362
- Issue:
- 6419
- Pages:
- eaat9446
- Publication date:
- 2018-12-07
- Acceptance date:
- 2018-10-18
- DOI:
- EISSN:
-
1095-9203
- ISSN:
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0036-8075
- Pubs id:
-
pubs:951531
- URN:
-
uri:d9357649-0500-41bb-af26-c8aa7cbfd2eb
- UUID:
-
uuid:d9357649-0500-41bb-af26-c8aa7cbfd2eb
- Local pid:
- pubs:951531
- Language:
- English
- Keywords:
- Copyright holder:
- Antonova-Koch et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- License:
- CC BY
Journal article
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
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Bill and Melinda Gates Foundation
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Medicines for Malaria Venture
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Wellcome Trust
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