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Populations of models: A new approach for understanding the mechanisms of atrial fibrillation

Abstract:

Inter-subject variability explains the diverging effects to pharmacological treatments of AF reported in the literature. A population of 173 mathematical models of remodeled human atrial tissue with realistic inter–subject variability was developed based on action potential recordings of 149 patients diagnosed with AF. The ranges of 6 biomarkers measured from the patch clamp studies were appropriately covered. The resulting population shows that multiple combinations of variations in the...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Authors


Liberos, A More by this author
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Department:
Oxford, MPLS, Computer Science
Rodrigo, M More by this author
Hernandez, I More by this author
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Universitat Politècnica de València More from this funder
Spanish Society of Cardiology More from this funder
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Publisher:
Sociedad Española de Ingeniería Biomédica Publisher's website
Publication date:
2016-10-05
Acceptance date:
2016-10-20
Pubs id:
pubs:653375
URN:
uri:d9346d3b-4a20-45c7-a434-9ade72ac131a
UUID:
uuid:d9346d3b-4a20-45c7-a434-9ade72ac131a
Local pid:
pubs:653375

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