Journal article
A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity
- Abstract:
- BA.2.86, a recently described sublineage of SARS-CoV-2 Omicron, contains many mutations in the spike gene. It appears to have originated from BA.2 and is distinct from the XBB variants responsible for many infections in 2023. The global spread and plethora of mutations in BA.2.86 has caused concern that it may possess greater immune-evasive potential, leading to a new wave of infection. Here, we examine the ability of BA.2.86 to evade the antibody response to infection using a panel of vaccinated or naturally infected sera and find that it shows marginally less immune evasion than XBB.1.5. We locate BA.2.86 in the antigenic landscape of recent variants and look at its ability to escape panels of potent monoclonal antibodies generated against contemporary SARS-CoV-2 infections. We demonstrate, and provide a structural explanation for, increased affinity of BA.2.86 to ACE2, which may increase transmissibility.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 7.4MB, Terms of use)
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- Publisher copy:
- 10.1016/j.xcrm.2024.101553
Authors
+ Medical Research Council
More from this funder
- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MR/W02067X/1
- MR/X009297/1
+ National Institutes of Health
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- Funder identifier:
- https://ror.org/01cwqze88
- Grant:
- U19 I082360
+ Wellcome Trust
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- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 203141/A/16/Z
- 101122/Z/13/Z
- 226120/Z/22/Z
- WT222426/Z/21/Z
- 207537/Z/17/Z
- 090532/Z/09/Z
- 203141/Z/16/Z
+ China Academy of Chinese Medical Sciences
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- Funder identifier:
- https://ror.org/042pgcv68
- Grant:
- 2018-I2M-2-002
- Publisher:
- Cell Press
- Journal:
- Cell Reports Medicine More from this journal
- Volume:
- 5
- Issue:
- 5
- Pages:
- 101553-101553
- Article number:
- 101553
- Place of publication:
- United States
- Publication date:
- 2024-05-08
- Acceptance date:
- 2024-04-11
- DOI:
- EISSN:
-
2666-3791
- ISSN:
-
2666-3791
- Pmid:
-
38723626
- Language:
-
English
- Keywords:
- Pubs id:
-
1995567
- UUID:
-
uuid_d9337d59-ce38-4992-9c2b-f6a30293b89a
- Local pid:
-
pubs:1995567
- Source identifiers:
-
W4396750360
- Deposit date:
-
2025-02-11
- ARK identifier:
Terms of use
- Copyright holder:
- Liu et al.
- Copyright date:
- 2024
- Rights statement:
- © 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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