Journal article
13CHD2 methyl group probes of millisecond time scale exchange in proteins by 1H relaxation dispersion: an application to proteasome gating residue dynamics.
- Abstract:
-
A pulse scheme is presented for quantifying millisecond time scale chemical exchange processes in proteins by measuring (1)H CPMG relaxation dispersion profiles of (13)CHD(2) methyl groups. The use of (13)CHD(2) isotopomers for (1)H methyl dispersion experiments eliminates problems with interconversion between differentially relaxing proton transitions that complicate the extraction of accurate exchange parameters when (13)CH(3) probes are used. Good agreement is demonstrated between extracte...
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- Publication status:
- Published
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- Publisher copy:
- 10.1021/ja104578n
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Bibliographic Details
- Journal:
- Journal of the American Chemical Society
- Volume:
- 132
- Issue:
- 32
- Pages:
- 10992-10995
- Publication date:
- 2010-08-05
- DOI:
- EISSN:
-
1520-5126
- ISSN:
-
0002-7863
- URN:
-
uuid:d9278129-bc31-452f-b0ba-71c89a43c79b
- Source identifiers:
-
386643
- Local pid:
- pubs:386643
Item Description
Terms of use
- Copyright date:
- 2010
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