Journal article

Catalytic strategies of the non-heme iron dependent oxygenases and their roles in plant biology

Abstract:: Non-heme iron-dependent oxygenases catalyse the incorporation of O2 into a wide range of biological molecules and use diverse strategies to activate their substrates. Recent kinetic studies, including in crystallo, have provided experimental support for some of the intermediates used by different subclasses of this enzyme family. Plant non-heme irondependent oxygenases have diverse and important roles, including in growth signalling, stress responses and secondary metabolism. Recently identified roles include in strigolactone biosynthesis, O-demethylation in morphine biosynthesis and regulating the stability of hypoxia-responsive transcription factors. We discuss current structural and mechanistic understanding of plant non-heme iron oxygenases, and how chemical/genetic manipulation could have agricultural benefit e.g. for improved yield, stress tolerance or herbicide development.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

White, M., & Flashman, E. (2016). Catalytic strategies of the non-heme iron dependent oxygenases and their roles in plant biology. Current Opinion in Chemical Biology, 31, 126–135.

MLA Style

White, M., and E. Flashman. “Catalytic Strategies of the Non-Heme Iron Dependent Oxygenases and Their Roles in Plant Biology.” Current Opinion in Chemical Biology, vol. 31, Elsevier, 2016, pp. 126–35.

Chicago Style

White, M, and E Flashman. 2016. “Catalytic Strategies of the Non-Heme Iron Dependent Oxygenases and Their Roles in Plant Biology.” Current Opinion in Chemical Biology 31: 126–35.
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Files:: White-and-Flashman.pdf

(Preview, Version of record, pdf, 1008.6KB, Terms of use)

Publisher copy:: 10.1016/j.cbpa.2016.02.017

Authors

+ White, M More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Flashman, E More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Royal Society More from this funder

Grant:: Dorothy Hodgkin Research Fellowship

+ Biotechnological and Biological Sciences Research Council More from this funder

Grant:: BB/M024458/1

Publisher:: Elsevier
Journal:: Current Opinion in Chemical Biology More from this journal
Volume:: 31
Pages:: 126–135
Publication date:: 2016-03-23
Acceptance date:: 2016-02-26
DOI:: 10.1016/j.cbpa.2016.02.017
ISSN:: 1879-0402

Pubs id:: pubs:606907
UUID:: uuid:d8d437a1-7026-4bf7-a24e-ec0458dbae0b
Local pid:: pubs:606907
Source identifiers:: 606907
Deposit date:: 2016-03-01

Terms of use

Copyright holder:: White and Flashman
Copyright date:: 2016
Notes:: Copyright © 2016 The Authors. Published by Elsevier Ltd. This is an
open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Licence:: CC Attribution (CC BY)

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