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Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

Abstract:

Human and other animal cells deploy three closely related dioxygenases (PHD 1, 2 and 3) to signal oxygen levels by catalysing oxygen regulated prolyl hydroxylation of the transcription factor HIF. The discovery of the HIF prolyl-hydroxylase (PHD) enzymes as oxygen sensors raises a key question as to the existence and nature of non-HIF substrates, potentially transducing other biological responses to hypoxia. Over 20 such substrates are reported. We therefore sought to characterise their react...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.46490.001

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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
8
Issue:
2019
Article number:
e46490
Publication date:
2019-09-10
Acceptance date:
2019-07-22
DOI:
ISSN:
2050-084X
Pubs id:
pubs:1045731
UUID:
uuid:d8c7819e-9598-47d0-aed3-1751b8883f77
Source identifiers:
1045731
Local pid:
pubs:1045731

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