CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans.

Journal article

The CD45 (leucocyte common) antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor signalling in lymphocytes, and expression of different CD45 isoforms is associated with distinct functions. Here we describe a novel polymorphism in exon 4 (A54G) of the gene encoding CD45 (PTPRC) that results in an amino acid substitution of Thr-19 to Ala in exon 4. The 54G allele was identified in African Ugandan populations and was found with a suggestive but not statistically significant increase in frequency amongst HIV-seropositive Ugandans. This suggests that the 54G variant and CD45 splicing abnormalities might be associated with HIV infection.

Authors: Stanton, T; Boxall, S; Bennett, A; Kaleebu, P; Watera, C

• Publication status: Published
• Journal: Immunogenetics
• Volume: 56
• Issue: 2
• Pages: 107-110
• Publication date: 2004-05-01
• DOI: 10.1007/s00251-004-0668-z
• EISSN: 1432-1211
• ISSN: 0093-7711
• Language: English
• Keywords: Polymorphism, Genetic; Uganda; Antigens, CD45; Gene Frequency; Genetic Predisposition to Disease; Alternative Splicing; Amino Acid Substitution; Leukocytes, Mononuclear; HIV-1; Exons; Humans; HIV Seropositivity; HIV Infections