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Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria.

Abstract:

BACKGROUND: Plasmodium falciparum and Plasmodium vivax are co-endemic in the Asia-Pacific region. Their capacity to induce and sustain diverse T-cell responses underpins protective immunity. We compared T-cell responses to the largely conserved merozoite surface protein-5 (PfMSP5) during acute and convalescent falciparum and vivax malaria. METHODS: Lymphoproliferation and IFN--γ secretion to PfMSP5 and purified protein derivate were quantified in adults with falciparum (n=34), and vivax malar...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jiq166

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Journal:
The Journal of infectious diseases
Volume:
203
Issue:
8
Pages:
1192-1199
Publication date:
2011-04-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:d8ae8fae-6f26-45e8-8d50-d476092306b6
Source identifiers:
135096
Local pid:
pubs:135096

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