Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2

Journal article

NHA2, also known as SLC9B2, is an orphan intracellular Na+/H+ exchanger (NHE) that has been associated with arterial hypertension and diabetes mellitus in humans. The objective of this NCCR TransCure project was to define the physiological and molecular function of NHA2, to develop a high resolution kinetic transport assay for NHA2 and to identify specific and potent compounds targeting NHA2. In this review, we summarize the results of this highly interdisciplinary and interfaculty effort, led by the groups of Proffs. Jean-Louis Reymond, Christoph von Ballmoos and Daniel Fuster

Authors: Matsuoka, R; Fudim, R; Jung, S; Zhang, C; Bazzone, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Nature Structural & Molecular Biology
• Volume: 29
• Issue: 2
• Pages: 108-120
• Publication date: 2022-02-16
• DOI: 10.1038/s41594-022-00738-2
• EISSN: 1545-9985
• ISSN: 1545-9993
• Language: English
• Keywords: Sodium–hydrogen antiporter; Biochemistry; Antiporters; Transmembrane domain; Intracellular; Chemistry; Helix (gastropod); Receptor; Membrane; Biology; Structural biology; Pathogenesis; Sodium; Biophysics; Transmembrane protein; Cell biology; Antiporter