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Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays.

Abstract:

Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL) play a major role in control of viral replication. To understand the contribution of this antiviral response, an initial step is to fully define the specific epitopes targeted by CTL. These studies focused on CTL responses restricted by HLA-A*3002, one of the HLA-A molecules most prominent in African populations. To avoid the time-consuming effort and expense involved in culturing CTL prior to defining epitopes and rest...

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Journal:
Journal of virology
Volume:
75
Issue:
3
Pages:
1339-1347
Publication date:
2001-02-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:d8a06adf-0e3b-48cf-9b1c-7192ccf1bb1a
Source identifiers:
191048
Local pid:
pubs:191048

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