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Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis.

Abstract:

Metastasis is a frequent complication of cancer, yet the process through which circulating tumor cells form distant colonies is poorly understood. We have been able to observe the steps in early hematogenous metastasis by epifluorescence microscopy of tumor cells expressing green fluorescent protein in subpleural microvessels in intact, perfused mouse and rat lungs. Metastatic tumor cells attached to the endothelia of pulmonary pre-capillary arterioles and capillaries. Extravasation of tumor ...

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Publication status:
Published

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Publisher copy:
10.1038/71429

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Journal:
Nature medicine
Volume:
6
Issue:
1
Pages:
100-102
Publication date:
2000-01-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:d88d8dd1-914a-493f-89f9-0af421ce1e3e
Source identifiers:
131062
Local pid:
pubs:131062

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