Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis.

Journal article

Metastasis is a frequent complication of cancer, yet the process through which circulating tumor cells form distant colonies is poorly understood. We have been able to observe the steps in early hematogenous metastasis by epifluorescence microscopy of tumor cells expressing green fluorescent protein in subpleural microvessels in intact, perfused mouse and rat lungs. Metastatic tumor cells attached to the endothelia of pulmonary pre-capillary arterioles and capillaries. Extravasation of tumor ...

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Authors: Al-Mehdi, AB; Tozawa, K; Fisher, AB; Shientag, L; Lee, A

• Publication status: Published
• Journal: Nature medicine
• Volume: 6
• Issue: 1
• Pages: 100-102
• Publication date: 2000-01-01
• DOI: 10.1038/71429
• EISSN: 1546-170X
• ISSN: 1078-8956
• Language: English
• Keywords: Fibrosarcoma; Mice, Nude; Rats; Mice; Genes, Reporter; Endothelium, Vascular; Tumor Cells, Cultured; Neoplasm Metastasis; Green Fluorescent Proteins; Lung Neoplasms; Microcirculation; Humans; Pulmonary Circulation; Female; Transfection; Animals; Rats, Sprague-Dawley; Transplantation, Heterologous; Cell Adhesion; Luminescent Proteins