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Routine versus clinically driven laboratory monitoring and first-line antiretroviral therapy strategies in African children with HIV (ARROW): a 5-year open-label randomised factorial trial.

Abstract:

BACKGROUND: No trials have investigated routine laboratory monitoring for children with HIV, nor four-drug induction strategies to increase durability of first-line antiretroviral therapy (ART). METHODS: In this open-label parallel-group trial, Ugandan and Zimbabwean children or adolescents with HIV, aged 3 months to 17 years and eligible for ART, were randomly assigned in a factorial design. Randomisation was to either clinically driven monitoring or routine laboratory and clinical monitorin...

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Journal:
Lancet
Volume:
381
Issue:
9875
Pages:
1391-1403
Publication date:
2013-04-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:d851d8a3-4be0-43d3-9050-bf056f101f1c
Source identifiers:
444410
Local pid:
pubs:444410

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