Association of incident amelanotic melanoma with phenotypic characteristics, MC1R status, and prior amelanotic melanoma

Journal article

Importance

We previously reported that survival is poorer from histopathologically amelanotic than pigmented melanoma because of more advanced stage at diagnosis. Identifying patients at risk of amelanotic melanoma might enable earlier diagnosis and improved survival; however, the phenotypic characteristics and underlying genetics associated with amelanotic melanoma are unknown.

Objective

To determine whether phenotypic characteristics, carriage of MC1R variants, ...

Expand abstract

Authors: Vernali, S; Waxweiler, W; Dillon, P; Kanetsky, P; Orlow, I

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Medical Association
• Journal: JAMA Dermatology
• Volume: 153
• Issue: 10
• Pages: 1026-1031
• Publication date: 2017-07-26
• Acceptance date: 2017-05-25
• DOI: 10.1001/jamadermatol.2017.2444
• EISSN: 2168-6084
• ISSN: 2168-6068
• Pmid: 28746718
• Language: English
• Keywords: female; melanoma, amelanotic; humans; middle aged; aged; male; phenotype; logistic models; adult; receptor, melanocortin, type 1; pigmentation; cohort studies; GEM Study Group; skin neoplasms