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HIV-1 progression links with viral genetic variability and subtype, and patient's HLA type: analysis of a Nairobi-Kenyan cohort.

Abstract:

In a Nairobi-Kenyan cohort of 50 HIV-1 positive patients, we analysed the prevalence of HIV-1 subtypes and human leucocyte antigen (HLA) alleles. From this cohort, 33 patients were selected for the analysis of HIV-1 infection progression markers (i.e. CD4 cell counts and viral loads) and their association with HIV-1 genetic variability and subtype, and patient's HLA type. HIV-1 gag genetic variability, analysed using bioinformatics tools, showed an inverse relationship with CD4 cell count whe...

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Publication status:
Published

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Publisher copy:
10.1007/s00430-013-0314-1

Authors


Lakhani, LS More by this author
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Journal:
Medical microbiology and immunology
Volume:
203
Issue:
1
Pages:
57-63
Publication date:
2014-02-05
DOI:
EISSN:
1432-1831
ISSN:
0300-8584
URN:
uuid:d8251550-45aa-468a-b412-fa8609b03bd3
Source identifiers:
436081
Local pid:
pubs:436081

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