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Modelling the response of vascular tumours to chemotherapy: A multiscale approach

Abstract:

An existing multiscale model is extended to study the response of a vascularised tumour to treatment with chemotherapeutic drugs which target proliferating cells. The underlying hybrid cellular automaton model couples tissue-level processes (e.g. blood flow, vascular adaptation, oxygen and drug transport) with cellular and subcellular phenomena (e.g. competition for space, progress through the cell cycle, natural cell death and drug-induced cell kill and the expression of angiogenic factors)....

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Publication date:
2006-07-05
URN:
uuid:d802f569-2907-4960-a2ac-d0e11fa47eb2
Local pid:
oai:eprints.maths.ox.ac.uk:316

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