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Dissection of mechanical force in living cells by super-resolved traction force microscopy

Abstract:

Cells continuously exert or respond to mechanical force. Measurement of these nanoscale forces is a major challenge in cell biology; yet such measurement is essential to the understanding of cell regulation and function. Current methods for examining mechanical force generation either necessitate dedicated equipment or limit themselves to coarse-grained force measurements on the micron scale. In this protocol, we describe stimulated emission depletion traction force microscopy-STED-TFM (STFM)...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nprot.2017.009

Authors


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Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
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Department:
Christ Church
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Department:
Balliol College
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Grant:
MC_UU_12010/unit programme G0902418
Wolfson Foundation More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Protocols Journal website
Volume:
12
Issue:
4
Pages:
783–796
Publication date:
2017-03-16
DOI:
EISSN:
1750-2799
ISSN:
1754-2189
Pubs id:
pubs:687021
URN:
uri:d8029b26-3c17-421e-bbf2-d5dd58a6c62b
UUID:
uuid:d8029b26-3c17-421e-bbf2-d5dd58a6c62b
Local pid:
pubs:687021

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