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Genome-wide genetic analyses highlight MAPK signalling in the pathogenesis of endometriosis

Abstract:

Study Question

Do genome-wide association study (GWAS) data for endometriosis provide insight into novel biological pathways associated with its pathogenesis?

Summary Answer

GWAS analysis uncovered multiple pathways that are statistically enriched for genetic association signals, analysis of Stage A disease highlighted a novel variant in MAP3K4, while top pathways significantly associated with all endometriosis and Stage A disease included several mitogen-activate...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/humrep/dex024

Authors


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Department:
Oxford, MSD, Obstetrics & Gynaecology
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Department:
Oxford, MSD, Obstetrics & Gynaecology
Missmer, S More by this author
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Funding agency for:
Rahmioglu, N
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Funding agency for:
Morris, AP
Publisher:
Oxford University Press Publisher's website
Journal:
Human Reproduction Journal website
Publication date:
2017-02-05
Acceptance date:
2017-01-24
DOI:
ISSN:
1460-2350
Pubs id:
pubs:671165
URN:
uri:d7f9fb3e-6faf-4911-ad15-ff67a1c09037
UUID:
uuid:d7f9fb3e-6faf-4911-ad15-ff67a1c09037
Local pid:
pubs:671165

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