Journal article
Genome-wide genetic analyses highlight MAPK signalling in the pathogenesis of endometriosis
- Abstract:
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Study Question
Do genome-wide association study (GWAS) data for endometriosis provide insight into novel biological pathways associated with its pathogenesis?
Summary Answer
GWAS analysis uncovered multiple pathways that are statistically enriched for genetic association signals, analysis of Stage A disease highlighted a novel variant in MAP3K4, while top pathways significantly associated with all endometriosis and Stage A disease included several mitogen-activate...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, pdf, 841.5KB, Terms of use)
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- Publisher copy:
- 10.1093/humrep/dex024
Authors
+ Medical Research Council
More from this funder
- Funding agency for:
- Rahmioglu, N
- Grant:
- MR/K011480/1
- Publisher:
- Oxford University Press
- Journal:
- Human Reproduction More from this journal
- Publication date:
- 2017-02-01
- Acceptance date:
- 2017-01-24
- DOI:
- ISSN:
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1460-2350
- Keywords:
- Pubs id:
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pubs:671165
- UUID:
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uuid:d7f9fb3e-6faf-4911-ad15-ff67a1c09037
- Local pid:
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pubs:671165
- Deposit date:
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2017-03-06
- ARK identifier:
Terms of use
- Copyright holder:
- Zondervan et al
- Copyright date:
- 2017
- Notes:
- © The Authors 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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